Alexis K. Edgerton
Research Scientist, In Vivo Pharmacology
San Diego, CA · (858) 555 0173 · name@example.com · linkedin.com/in/alexiskedgerton
Key Qualifications
EXPERIENCE
Seven years of in vivo pharmacology in drug discovery
THERAPEUTIC AREAS
Solid tumor oncology, immuno oncology
SPECIALTIES
Xenograft and syngeneic model design, dose response studies, pharmacodynamic biomarkers
SYSTEMS
GraphPad Prism, laboratory information management system, Benchling, FlowJo
CREDENTIALS
Member of the American Association for Cancer Research
EDUCATION
Doctor of philosophy in cancer biology, University of California, San Diego
Executive Summary
Research scientist running in vivo pharmacology for two oncology programs. Seven years at the bench since the doctorate, designing tumor growth studies, reading out efficacy and pharmacodynamics, and writing the nonclinical sections that go into an investigational new drug application.
Signature Achievements
- Designed and ran the efficacy package that supported a development candidate decision on a first program.
- Established four tumor models in house and cut study start time from nine weeks to three.
- Showed target engagement in tumor tissue at two dose levels, which set the starting dose for the first study in people.
- Reduced animal use by 28 percent across the program by moving to a group size justified with power calculations in GraphPad Prism.
- Wrote the pharmacology summary in an investigational new drug application that drew no questions from the review division.
- Published two first author papers and presented the lead program at a national oncology meeting.
Professional Experience
Research Scientist, In Vivo Pharmacology
La Jolla Oncology Discovery, San Diego, CA 2022 to present
Runs in vivo pharmacology for two discovery programs at a company of 140 people, working with two associates.
- Designs efficacy, dose response and pharmacodynamic studies and analyzes the results.
- Maintains the model bank and the protocols approved by the animal care and use committee.
- Writes study reports and the nonclinical content used in regulatory filings.
- Presents data at program team meetings and recommends the next set of experiments.
Scientist, Pharmacology
Pacific Coast Biosciences, Carlsbad, CA 2019 to 2022
Supported three early discovery programs in a contract research setting.
- Executed tumor growth inhibition studies for external sponsors.
- Developed tissue collection and analysis methods for biomarker readouts.
- Trained junior staff on dosing technique and humane endpoints.
Licensure and Certification
Member, American Association for Cancer Research
Certified Professional in Laboratory Animal Science, American Association for Laboratory Animal Science
Education
Doctor of philosophy in cancer biology, University of California, San Diego
Bachelor of science in biology, University of California, Davis
Core Skills
In vivo study design · Xenograft models · Pharmacodynamic biomarkers · Dose response analysis · GraphPad Prism · Flow cytometry · Animal protocol writing · Study reports · Nonclinical writing · Data presentation